Electrospun Fibres of Chitosan/PVP for the Effective Chemotherapeutic Drug Delivery of 5-Fluorouracil

Electrospun nanofibrous mats consisting of chitosan (CS) and polyvinylpyrrolidone (PVP) were constructed. Tuning solution process parameters was performed resulted in an electrospun system containing a 6:4 ratio PVP:CS. This is significant increase the proportion spun CS on previously reported highest PVP:CS blend. SEM analysis showed that with 4 wt% CS/6 PVP (sample E) comprised homogenous, uniform fibres average diameter 0.569 μm. XPS surface samples consisted PVP. Raman FTIR revealed intermolecular interactions (via H-bonding) between CS. In spectra, contribution to CS/PVP complexes shown by downshift C=O band linear intensity C-O stretching smaller shift at binding energy 531 eV, which relates amide acetylated functional groups. The obtained results demonstrate sensitivity tests presence chemotherapy drug 5-Fu incorporated into constructs cell viability studies performed. WST-8 assay exposure A549 human alveolar basal epithelial cells 10 mg/mL loaded most effective killing over 24 h. On other hand, loading 1 not efficient cells. study CS/PVP/5-Fu have potential chemotherapeutic delivery systems.